CLINICAL TRIALS AND OBSERVATIONS Zosuquidar, a novel modulator of P-glycoprotein, does not improve the outcome of older patients with newly diagnosed acute myeloid leukemia: a randomized, placebo-controlled trial of the Eastern Cooperative Oncology Group 3999
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چکیده
1Indiana University Simon Cancer Center, Indianapolis, IN; 2Dana-Farber Cancer Institute, Boston, MA; 3North Division of Montefiore Medical Center, Bronx, NY; 4Mayo Clinic, Rochester, MN; 5University of Rochester, Rochester, NY; 6Rambam Medical Center, Haifa, Israel; 7Case Comprehensive Cancer Center, Cleveland, OH; 8University of Pennsylvania, Philadelphia, PA; and 9Memorial Sloan-Kettering Cancer Center, New York, NY
منابع مشابه
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS A phase 3 study of three induction regimens and of priming with GM-CSF in older adults with acute myeloid leukemia: a trial by the Eastern Cooperative Oncology Group
The optimal induction for older adults with acute myeloid leukemia (AML) is unknown. Several anthracyclines have been proposed, but the data remain equivocal. Additionally, few prospective trials of priming with hematopoietic growth factors to cycle leukemia cells prior to induction chemotherapy have been conducted. Three hundred and sixtytwo older adults with previously untreated AML were rand...
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The treatment of older patients with acute myeloid leukemia (AML) remains unsatisfactory, with complete remission (CR) achieved in only approximately 50% and long-term disease-free survival in 10% to 20%. Three hundred eighty-eight patients (60 years of age and older) with newly diagnosed de novo AML were randomly assigned to receive placebo (P) or granulocyte-macrophage colony-stimulating fact...
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1North Shore University Hospital, Hofstra University School of Medicine, Lake Success; 2Cancer and Leukemia Group B Statistical Center, Durham, NC; 3The Ohio State University, Columbus; 4Washington University School of Medicine, St Louis, MO; 5Comprehensive Cancer Center of Wake Forest University, Winston-Salem, NC; 6North Shore University Hospital, Albert Einstein College of Medicine, Lake Suc...
متن کاملCLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS Attempts to improve treatment outcomes in acute myeloid leukemia (AML) in older patients: the results of the United Kingdom Medical Research Council AML11 trial
In an attempt to improve induction chemotherapy for older patients with acute myeloid leukemia (AML),1314 patients were randomized to 1 of 3 induction treatments for 2 courses of DAT (daunorubicin, cytarabine, and thioguanine) 3 1 10, ADE (daunorubicin, cytarabine, and etoposide) 10 1 3 1 5, or MAC (mitoxantronecytarabine). The remission rate in the DAT arm was significantly better than ADE (62...
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تاریخ انتشار 2010